KCNB1 is a voltage-gated potassium channel. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Those with a KCNB1 genetic mutation typically suffer encephalopathy, refractory seizures, polyseizure profiles, developmental delay, hypotonia, movement disorders, cognitive impairment and a higher risk of SUDEP (sudden unexpected death due to Epilepsy). At this time, only 11 people have been identified in the world with this genetic mutation. We are a small but mighty group of families that are connected together because of KCNB1. We are working together to find answers, share information, find ways to improve our children?s lives, and ultimately find a cure. Please visit www.kcnb1.org for additional information.