Oxidative Stress

Difficulty: Fiendish-- Oxidative stress can cause proteins to misfold and accumulate in the endoplasmic reticulum (ER). This can trigger the ER stress response (including the Unfolded Protein Response) a cellular stress response crucial for protein homeostasis. Issues with overactivation of the unfolded protein response (UPR) have been associated with a number of neurodegenerative diseases. N-glycanase 1 is important for cleaving sugar molecules off of proteins allowing them to be degraded. NGLY1 deficiency would be expected to cause N-glycosylated protein accumulation. Can we learn more about the issues caused by protein accumulation and ultimately the symptoms of NGLY1 by investigating Oxidative stress and UPR? Help us find out!

Community progress on this set:

Top doc set contributors:
  • ckrypton

  • Isabelle

  • mariomar_it

  • TAdams

  • aprilwent

Group Statistics
  1. Total number of contributors: 61

  2. Total documents: 444

  3. Current average f-score: 0.000

  4. Start date: 2015.07.31

  5. End date: 2016.04.03

Top contributor word cloud: