Difficulty: Medium/Hard-- Misfolded proteins can aggregate and trigger the endoplasmic reticulum (ER) stress response which affects normal cellular processes like autophagy and mitochondrial function. Mitochondria play a key role in producing energy for the cell and mitochondrial dysfunction is linked with many different diseases such as Leber's hereditary optic neuropathy, Friedreich's ataxia, Wilson's disease, hereditary spastic paraplegia, and more. Deficiency in N-glycanase 1 is expected to result in the aggregation of N-glycosylated proteins. Does the literature surrounding protein misfolding and mitochondrial function hold clues about the mechanism of disease progression in NGLY1 deficiency? Mark the docs to help us find out!