As another clue identified by multiple Mark2Curators across multiple missions, CHOP (C/EBP homologous protein) is a pro-apoptotic transcription factor encoded by the DNA damage-inducible transcript 3 (DDIT3) gene. At a first glance, it is not clear how CHOP might be a useful clue for understanding NGLY1-deficiency. If we delve a little deeper on the subject, CHOP is important for cellular homeostasis and NOT just apoptosis. Improper glycosylation or disruptions in glycosylation can trigger the unfolded protein response and induce the expression of CHOP ultimately leading to apoptosis. Strangely enough, CHOP has been found to be required for neuronal survival after seizures and to reduce seizure-induced hippocampal damage in mice. How does a protein that activates apoptosis during ER stress and the unfolded protein response help protect against seizure-induced damage? What role might CHOP have on the symptoms of NGLY1-deficiency? Help us unlock the mystery of CHOP from the literature. Contribute now!
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