Myelin and Autophagy

Myelin is an outgrowth of a type of glial cell that is essential for the proper functioning of the nervous system. Demyelination, or the loss of myelin sheaths is observed in many diseases such as Multiple Sclerosis, Charcot-Marie-Tooth disease, and more. Autophagy is a crucial biological process that allows cells to degrade and recycle cellular components including myelin. How might autophagy be perturbed in NGLY1-deficiency? Are there links between autophagy perturbations and symptoms of NGLY1-deficiency? Are there modulators of autophagy which could potentially be used as therapeutics for NGLY1-deficiency? Help us find out by marking the docs in this quest.

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