Difficulty: Medium/Hard-- Autophagy is a crucial biological process that allows cells to degrade and recycle cellular components. It is required for proper cell homeostasis, and alterations in autophagy have been linked to arthritis, cancer, infectious disease, and more. NGLY1-deficiency is expected to cause aggregation of glycoproteins. How might autophagy be perturbed in NGLY1-deficiency? Are there links between autophagy perturbations and symptoms of NGLY1-deficiency? Are there modulators of autophagy which could potentially be used as therapeutics for NGLY1-deficiency? Help us find out by marking the docs in this quest.
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